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Thursday, April 3, 2025

Strategies proposed to prevent H5N1 bird flu epidemic

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John Taylor, Professor of Economics at Stanford University and developer of the "Taylor Rule" for setting interest rates | Stanford University

John Taylor, Professor of Economics at Stanford University and developer of the "Taylor Rule" for setting interest rates | Stanford University

The threat posed by the H5N1 bird flu virus is under the spotlight, due to its potential to not only increase egg prices nationally but also transform into a major health crisis. The concerns stem from potential human, poultry, and cattle cross-contaminations. Abraar Karan, MD, an expert in infectious diseases at Stanford Medicine, emphasized the importance of early preventive measures.

Karan, with colleagues, contributed to a recent Nature commentary outlining tactics to curb the virus's evolution into more dangerous forms. Suggestions include enhancing farmworkers' access to personal protective equipment, consistent testing of dairy products, improved surveillance systems, and educational initiatives to counteract disinformation.

Addressing why investments are vital despite the Centers for Disease Control and Prevention's low-risk assessment, Karan remarked, "It is true that the H5N1 virus is not transmitting efficiently between people... But the moment you get into an accident, you could be dead." He stressed the necessity to prepare against a potential epidemic now.

Key concerns hinge on the virus's ability to become more transmissible and severe by exchanging gene segments when co-infection occurs in humans and animals. Karan noted, "Expanding genomic and human surveillance through regular testing... can help inform us of how the virus is mutating."

Vaccine development is ongoing but faces challenges. Existing vaccines are not significantly effective, and rapid mutation of the virus presents obstacles. Moderna's $600 million experimental vaccine initiative highlights ongoing efforts, though the new administration is reassessing funding priorities.

In terms of direct action, Karan argues for the importance of PPE programs in minimizing transmissions from livestock to humans, particularly noting previous incidents where inadequate PPE usage resulted in infections.

Joining Karan in the findings are Ranu S. Dhillon from Brigham and Women's Hospital, Robert F. Garry from Tulane University, and Devabhaktuni Srikrishna from Patient Knowhow. The importance of these strategies was underscored by prior insufficient responses to similar pandemics.

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